LIN28B (NM_001004317) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC213537L1V
- LentiORF®
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Lenti ORF particles, LIN28B (Myc-DDK tagged) - Human lin-28 homolog B (C. elegans) (LIN28B), 200ul, >10^7 TU/mL
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CNY 7,410.00
货期*
详询
规格
Cited in 3 publications. |
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经常一起买 (3)
Specifications
Product Data | |
Product Name | LIN28B (NM_001004317) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | CSDD2 |
Vector | pLenti-C-Myc-DDK |
ACCN | NM_001004317 |
ORF Size | 750 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC213537).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_001004317.2 |
RefSeq Size | 5504 bp |
RefSeq ORF | 753 bp |
Locus ID | 389421 |
MW | 26.9 kDa |
Gene Summary | The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012] |
Citations (3)
The use of this cDNA Clones has been cited in the following citations: |
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Carbon ion irradiation abrogates Lin28B-induced X-ray resistance in melanoma cells
,null,
Journal of Radiation Research
,PubMed ID 28482074
[LIN28B]
|
MacroH2A1 downregulation enhances the stem-like properties of bladder cancer cells by transactivation of Lin28B
,null,
Oncogene
,PubMed ID 26028027
[LIN28B]
|
Overexpression of the RNA-binding proteins Lin28B and IGF2BP3 (IMP3) is associated with chemoresistance and poor disease outcome in ovarian cancer
,null,
British Journal of Cancer
,PubMed ID 26158423
[LIN28B]
|
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