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VRK1 (NM_003384) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC210764L3V
- LentiORF®
-
Lenti ORF particles, VRK1 (Myc-DDK tagged) - Human vaccinia related kinase 1 (VRK1), 200ul, >10^7 TU/mL
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Specifications
| Product Data | |
| Product Name | VRK1 (NM_003384) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | PCH1; PCH1A |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_003384 |
| ORF Size | 1188 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC210764).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_003384.2 |
| RefSeq Size | 1720 bp |
| RefSeq ORF | 1191 bp |
| Locus ID | 7443 |
| Domains | pkinase, S_TKc |
| Protein Families | Druggable Genome, Protein Kinase |
| MW | 45.3 kDa |
| Gene Summary | This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008] |
Documents
| Product Manuals |
| FAQs |
| SDS |
