C9orf72 (NM_018325) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC209700L1V
- LentiORF®
-
Lenti ORF particles, C9orf72 (Myc-DDK tagged) - Human chromosome 9 open reading frame 72 (C9orf72), transcript variant 2, 200ul, >10^7 TU/mL
Need custom lentivirus service?
Get a free quote
CNY 8,930.00
货期*
详询
规格
Cited in 2 publications. |
Product images
![](https://cdn.origene.com/img/defaults-img.jpg)
经常一起买 (3)
Specifications
Product Data | |
Product Name | C9orf72 (NM_018325) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | ALSFTD; DENND9; DENNL72; FTDALS; FTDALS1 |
Vector | pLenti-C-Myc-DDK |
ACCN | NM_018325 |
ORF Size | 1443 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC209700).
|
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_018325.1 |
RefSeq Size | 3244 bp |
RefSeq ORF | 1446 bp |
Locus ID | 203228 |
MW | 54.3 kDa |
Gene Summary | The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2016] |
Citations (2)
The use of this cDNA Clones has been cited in the following citations: |
---|
Novel antibodies reveal presynaptic localization of C9orf72 protein and reduced protein levels in C9orf72 mutation carriers
,null,
Acta Neuropathologica Communications
,PubMed ID 30075745
[C9orf72]
|
Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes
,null,
Human Molecular Genetics
,PubMed ID 27126638
[C9orf72]
|
Documents
Product Manuals |
FAQs |
SDS |
Resources
You may also need
其它C9orf72产品
Customer
Reviews
Loading...