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ALKBH5 (NM_017758) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC209110L3V
- LentiORF®
-
Lenti ORF particles, ALKBH5 (Myc-DDK tagged) - Human alkB, alkylation repair homolog 5 (E. coli) (ALKBH5), 200ul, >10^7 TU/mL
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CNY 8,265.00
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| Product Data | |
| Product Name | ALKBH5 (NM_017758) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | ABH5; OFOXD; OFOXD1 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_017758 |
| ORF Size | 1374 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC209110).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_017758.2, NP_060228.2 |
| RefSeq Size | 3449 bp |
| RefSeq ORF | 1185 bp |
| Locus ID | 54890 |
| Domains | 2OG-FeII_Oxy |
| MW | 51.4 kDa |
| Gene Summary | Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3' UTR mRNAs in male germ cells (By similarity).[UniProtKB/Swiss-Prot Function] |
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