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NYREN18 (NUB1) (NM_016118) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC208098L3V
- LentiORF®
-
Lenti ORF particles, NUB1 (Myc-DDK tagged) - Human negative regulator of ubiquitin-like proteins 1 (NUB1), 200ul, >10^7 TU/mL
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CNY 10,640.00
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CNY 2,950.00
CNY 1,999.00
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Specifications
| Product Data | |
| Product Name | NYREN18 (NUB1) (NM_016118) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | BS4; NUB1L; NYREN18 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_016118 |
| ORF Size | 1803 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC208098).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_016118.3, NP_057202.2 |
| RefSeq Size | 3112 bp |
| RefSeq ORF | 1806 bp |
| Locus ID | 51667 |
| Domains | UBA |
| Protein Families | Druggable Genome |
| MW | 68.9 kDa |
| Gene Summary | This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011] |
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