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IFIT5 (NM_012420) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC206499L3V
- LentiORF®
-
Lenti ORF particles, IFIT5 (Myc-DDK tagged) - Human interferon-induced protein with tetratricopeptide repeats 5 (IFIT5), 200ul, >10^7 TU/mL
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CNY 8,930.00
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Specifications
| Product Data | |
| Product Name | IFIT5 (NM_012420) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | ISG58; P58; RI58 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_012420 |
| ORF Size | 1446 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC206499).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_012420.1, NP_036552.1 |
| RefSeq Size | 4034 bp |
| RefSeq ORF | 1449 bp |
| Locus ID | 24138 |
| Domains | TPR |
| MW | 55.8 kDa |
| Gene Summary | Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments (PubMed:25092312, PubMed:23317505, PubMed:23774268). Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner (PubMed:23334420). Also recognizes and selectively binds AT-rich dsDNA (PubMed:23774268). Additionally, as a mediator in innate immunity, regulates positively IKK-NFKB signaling by sinergizing the recruitment of IKK to MAP3K7 (PubMed:26334375).[UniProtKB/Swiss-Prot Function] |
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