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AF9 (MLLT3) (NM_004529) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC206283L3V
- LentiORF®
-
Lenti ORF particles, MLLT3 (Myc-DDK tagged) - Human myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (MLLT3), 200ul, >10^7 TU/mL
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CNY 8,930.00
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Specifications
| Product Data | |
| Product Name | AF9 (MLLT3) (NM_004529) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | AF9; YEATS3 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_004529 |
| ORF Size | 1704 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC206283).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_004529.1 |
| RefSeq Size | 6787 bp |
| RefSeq ORF | 1707 bp |
| Locus ID | 4300 |
| Domains | YEATS |
| Protein Families | Transcription Factors |
| MW | 63.3 kDa |
| Gene Summary | Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a marked preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3 acetylated at 'Lys-9' (H3K9ac), but with lower affinity than crotonylated histone H3 (PubMed:25417107, PubMed:27105114). In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones (PubMed:27105114, PubMed:27545619).[UniProtKB/Swiss-Prot Function] |
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