C14orf169 (NM_024644) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC203678L3V
- LentiORF®
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Lenti ORF particles, C14orf169 (Myc-DDK-tagged)-Human chromosome 14 open reading frame 169 (C14orf169), 200ul, >10^7 TU/mL
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CNY 8,930.00
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Specifications
Product Data | |
Product Name | C14orf169 (NM_024644) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | C14orf169; hsNO66; JMJD9; MAPJD; NO66; ROX; URLC2 |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_024644 |
ORF Size | 1923 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC203678).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_024644.2 |
RefSeq Size | 2463 bp |
RefSeq ORF | 1926 bp |
Locus ID | 79697 |
Protein Families | Druggable Genome |
MW | 71.1 kDa |
Gene Summary | Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation.[UniProtKB/Swiss-Prot Function] |
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