Erbb2 (NM_001003817) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR227307L4V

  • LentiORF®

Lenti ORF particles, Erbb2 (GFP-tagged) - Mouse v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (Erbb2), 200ul, >10^7 TU/mL

ORF Plasmid: DDK tGFP



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CNY 20,140.00


货期*
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规格
    • 200 ul

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Specifications

Product Data
Product Name Erbb2 (NM_001003817) Mouse Tagged ORF Clone Lentiviral Particle
Synonyms c-erbB2; c-neu; Erbb-2; HER-2; HER2; l11Jus8; mKIAA3023; Neu
Vector pLenti-C-mGFP-P2A-Puro
ACCN NM_001003817
ORF Size 3768 bp
Sequence Data
The ORF insert of this clone is exactly the same as(MR227307).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq NM_001003817.1, NP_001003817.1
RefSeq Size 4998 bp
RefSeq ORF 3771 bp
Locus ID 13866
Gene Summary Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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