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Alox12 (NM_007440) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR227302L3V
- LentiORF®
-
Lenti ORF particles, Alox12 (Myc-DDK-tagged) - Mouse arachidonate 12-lipoxygenase (Alox12), 200ul, >10^7 TU/mL
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CNY 11,400.00
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规格
| Cited in 1 publication. |
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经常一起买 (2)
Specifications
| Product Data | |
| Product Name | Alox12 (NM_007440) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 9930022G08Rik; Alox12p; P-12LO |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_007440 |
| ORF Size | 1989 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR227302).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_007440.4 |
| RefSeq Size | 2991 bp |
| RefSeq ORF | 1992 bp |
| Locus ID | 11684 |
| Gene Summary | Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation.[UniProtKB/Swiss-Prot Function] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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12-lipoxygenase regulates cold adaptation and glucose metabolism by producing the omega-3 lipid 12-HEPE from brown fat
,null,
Cell metabolism
,PubMed ID 31353262
[Alox12]
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