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Il6st (NM_010560) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR226651L3V
- LentiORF®
-
Lenti ORF particles, Il6st (Myc-DDK-tagged) - Mouse interleukin 6 signal transducer (Il6st), 200ul, >10^7 TU/mL
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CNY 14,250.00
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Specifications
| Product Data | |
| Product Name | Il6st (NM_010560) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 5133400A03Rik; AA389424; BB405851; CD130; D13Ertd699e; gp130 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_010560 |
| ORF Size | 2751 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR226651).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_010560.3, NP_034690.3 |
| RefSeq Size | 5452 bp |
| RefSeq ORF | 2754 bp |
| Locus ID | 16195 |
| Gene Summary | Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:1602143). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:10661409). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (PubMed:10661409, PubMed:26255596, PubMed:25057188, PubMed:8552649). Has a role in embryonic development (PubMed:10661409). Does not bind IL6 (By similarity). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (PubMed:10377352). Required for expression of TRPA1 in nociceptive neurons (PubMed:25057188). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (PubMed:25228504). Required for normal trabecular bone mass and cortical bone composition (PubMed:24339143, PubMed:9348227, PubMed:26255596).[UniProtKB/Swiss-Prot Function] |
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