Wrn (NM_011721) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR226496L1V
- LentiORF®
Lenti ORF particles, Wrn (Myc-DDK-tagged) - Mouse Werner syndrome homolog (human) (Wrn), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 19,760.00
货期*
详询
规格
Cited in 1 publication. |
经常一起买 (2)
Specifications
Product Data | |
Product Name | Wrn (NM_011721) Mouse Tagged ORF Clone Lentiviral Particle |
Synonyms | AI846146 |
Vector | pLenti-C-Myc-DDK |
ACCN | NM_011721 |
ORF Size | 4203 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR226496).
|
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_011721.4, NP_035851.3 |
RefSeq Size | 6383 bp |
RefSeq ORF | 4206 bp |
Locus ID | 22427 |
Gene Summary | Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation (By similarity).[UniProtKB/Swiss-Prot Function] |
Citations (1)
The use of this cDNA Clones has been cited in the following citations: |
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Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice
,null,
PLoS ONE
,PubMed ID 26447695
[Wrn]
|
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