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Prdm6 (NM_001033281) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR224755L4V
- LentiORF®
-
Lenti ORF particles, Prdm6 (GFP-tagged) - Mouse PR domain containing 6 (Prdm6), 200ul, >10^7 TU/mL
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CNY 11,875.00
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Specifications
| Product Data | |
| Product Name | Prdm6 (NM_001033281) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | Gm92; PRISM |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_001033281 |
| ORF Size | 1788 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR224755).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001033281.3, NP_001028453.1 |
| RefSeq Size | 2601 bp |
| RefSeq ORF | 1791 bp |
| Locus ID | 225518 |
| Gene Summary | Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression (PubMed:16537907, PubMed:17662997). Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells (PubMed:27181681, PubMed:16537907, PubMed:17662997). Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a (PubMed:16537907). According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression (PubMed:17662997).[UniProtKB/Swiss-Prot Function] |
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