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Spn (NM_001037810) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR221850L3V
- LentiORF®
-
Lenti ORF particles, Spn (Myc-DDK-tagged) - Mouse sialophorin (Spn), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 7,410.00
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Specifications
| Product Data | |
| Product Name | Spn (NM_001037810) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | A630014B01Rik; Cd43; Galgp; Ly-48; Ly48 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001037810 |
| ORF Size | 1185 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR221850).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001037810.1, NP_001032899.1 |
| RefSeq Size | 1475 bp |
| RefSeq ORF | 1188 bp |
| Locus ID | 20737 |
| Gene Summary | Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (PubMed:17638845, PubMed:21289089, PubMed:11728336). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment (PubMed:18490738). Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells. Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (By similarity). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin (PubMed:26700769). Acts as a T-cell counter-receptor for SIGLEC1 (PubMed:11238599).[UniProtKB/Swiss-Prot Function] |
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