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Smc1a (NM_019710) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR221566L3V
- LentiORF®
-
Lenti ORF particles, Smc1a (Myc-DDK-tagged) - Mouse structural maintenance of chromosomes 1A (Smc1a), 200ul, >10^7 TU/mL
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CNY 17,860.00
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规格
| Cited in 1 publication. |
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经常一起买 (2)
Specifications
| Product Data | |
| Product Name | Smc1a (NM_019710) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 5830426I24Rik; mKIAA0178; Sb1.8; SMC-1A; Smc1; Smc1alpha; Smc1l1; Smcb |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_019710 |
| ORF Size | 3699 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR221566).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_019710.2, NP_062684.2 |
| RefSeq Size | 3980 bp |
| RefSeq ORF | 3702 bp |
| Locus ID | 24061 |
| Gene Summary | Involved in chromosome cohesion during cell cycle and in DNA repair. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, and works as a downstream effector in the ATM/NBS1 branch of S-phase checkpoint (By similarity). Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.[UniProtKB/Swiss-Prot Function] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Overexpression of the cohesin-core subunit SMC1A contributes to colorectal cancer development
,null,
Journal of Experimental & Clinical Cancer Research : CR
,PubMed ID 30823889
[Smc1a]
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