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Rnasel (NM_011882) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR219460L4V
- LentiORF®
-
Lenti ORF particles, Rnasel (GFP-tagged) - Mouse ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) (Rnasel), 200ul, >10^7 TU/mL
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CNY 13,585.00
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Specifications
| Product Data | |
| Product Name | Rnasel (NM_011882) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | E230029I04Rik |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_011882 |
| ORF Size | 2205 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR219460).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_011882.2, NP_036012.1 |
| RefSeq Size | 4758 bp |
| RefSeq ORF | 2208 bp |
| Locus ID | 24014 |
| Gene Summary | Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis. Might play a central role in the regulation of mRNA turnover (By similarity). Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length (By similarity).[UniProtKB/Swiss-Prot Function] |
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