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Nsmce2 (NM_026746) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR218993L3V
- LentiORF®
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Lenti ORF particles, Nsmce2 (Myc-DDK-tagged) - Mouse non-SMC element 2 homolog (MMS21, S. cerevisiae) (Nsmce2), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 7,410.00
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Specifications
| Product Data | |
| Product Name | Nsmce2 (NM_026746) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 1110014D18Rik; AI661537 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_026746 |
| ORF Size | 744 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR218993).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_026746.3, NP_081022.2 |
| RefSeq Size | 1159 bp |
| RefSeq ORF | 744 bp |
| Locus ID | 68501 |
| Gene Summary | E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair. Required for sister chromatid cohesion during prometaphase and mitotic progression (By similarity).[UniProtKB/Swiss-Prot Function] |
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