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Casc3 (NM_138660) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR218953L4V
- LentiORF®
-
Lenti ORF particles, Casc3 (GFP-tagged) - Mouse cancer susceptibility candidate 3 (Casc3), 200ul, >10^7 TU/mL
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CNY 13,110.00
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Specifications
| Product Data | |
| Product Name | Casc3 (NM_138660) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | Btz; Mln51 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_138660 |
| ORF Size | 2094 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR218953).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_138660.2, NP_619601.2 |
| RefSeq Size | 3764 bp |
| RefSeq ORF | 2097 bp |
| Locus ID | 192160 |
| Gene Summary | Required for pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homopolymer.[UniProtKB/Swiss-Prot Function] |
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