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Cfh (NM_009888) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR218690L3V
- LentiORF®
-
Lenti ORF particles, Cfh (Myc-DDK-tagged) - Mouse complement component factor h (Cfh), 200ul, >10^7 TU/mL
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CNY 18,050.00
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Specifications
| Product Data | |
| Product Name | Cfh (NM_009888) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | Mud-1; NOM; Sas-1; Sas1 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_009888 |
| ORF Size | 3756 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR218690).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_009888.3, NP_034018.2 |
| RefSeq Size | 4365 bp |
| RefSeq ORF | 3759 bp |
| Locus ID | 12628 |
| Gene Summary | Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed.[UniProtKB/Swiss-Prot Function] |
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