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Rspo3 (NM_028351) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR218621L3V
- LentiORF®
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Lenti ORF particles, Rspo3 (Myc-DDK-tagged) - Mouse R-spondin 3 homolog (Xenopus laevis) (Rspo3), 200ul, >10^7 TU/mL
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CNY 7,410.00
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Specifications
| Product Data | |
| Product Name | Rspo3 (NM_028351) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 2810459H04Rik; AW742308; Cristin1; Thsd2 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_028351 |
| ORF Size | 831 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR218621).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_028351.3, NP_082627.3 |
| RefSeq Size | 2411 bp |
| RefSeq ORF | 834 bp |
| Locus ID | 72780 |
| Gene Summary | Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis (PubMed:16543246, PubMed:21693646, PubMed:26766444). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:16543246, PubMed:21693646). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (PubMed:26766444, PubMed:16543246, PubMed:21693646). Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 (By similarity).[UniProtKB/Swiss-Prot Function] |
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