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Tank (NM_001164071) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR216880L3V
- LentiORF®
-
Lenti ORF particles, Tank (Myc-DDK-tagged) - Mouse TRAF family member-associated Nf-kappa B activator (Tank), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 7,410.00
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规格
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Specifications
| Product Data | |
| Product Name | Tank (NM_001164071) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | C86182; E430026L09Rik; I-TRAF |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001164071 |
| ORF Size | 1239 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR216880).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001164071.1, NP_001157543.1 |
| RefSeq Size | 2227 bp |
| RefSeq ORF | 1245 bp |
| Locus ID | 21353 |
| Gene Summary | Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage. Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage. Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage. May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Essential for the efficient induction of IRF-dependent transcription following infection with Sendai virus.[UniProtKB/Swiss-Prot Function] |
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