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Tnpo1 (NM_178716) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR216038L4V
- LentiORF®
-
Lenti ORF particles, Tnpo1 (GFP-tagged) - Mouse transportin 1 (Tnpo1), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 15,675.00
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Specifications
| Product Data | |
| Product Name | Tnpo1 (NM_178716) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AU021749; D13Ertd688e; IPO2; Kpnb2; MIP; MIP1; TRN |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_178716 |
| ORF Size | 2694 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR216038).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_178716.3, NP_848831.2 |
| RefSeq Size | 5391 bp |
| RefSeq ORF | 2697 bp |
| Locus ID | 238799 |
| Gene Summary | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11493596). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A (By similarity). In vitro, mediates nuclear import of SRP19 (By similarity). Mediates the import of histones H2A, H2B, H3 and H4 (PubMed:11493596). Mediates nuclear import of ADAR/ADAR1 in a RanGTP-dependent manner (By similarity).[UniProtKB/Swiss-Prot Function] |
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