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Top3a (NM_009410) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR211428L4V
- LentiORF®
-
Lenti ORF particles, Top3a (GFP-tagged) - Mouse topoisomerase (DNA) III alpha (Top3a), 200ul, >10^7 TU/mL
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CNY 16,910.00
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Specifications
| Product Data | |
| Product Name | Top3a (NM_009410) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | MGC106383 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_009410 |
| ORF Size | 3009 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR211428).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_009410.2 |
| RefSeq Size | 3740 bp |
| RefSeq ORF | 3012 bp |
| Locus ID | 21975 |
| Gene Summary | Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. As an essential component of the RMI complex it is involved in chromosome separation and the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNA decatenation activity. It is required for mtDNA decatenation and segregation after completion of replication, in a process that does not require BLM, RMI1 and RMI2.[UniProtKB/Swiss-Prot Function] |
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