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1500010J02Rik (BC060629) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR211335L3V
- LentiORF®
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Lenti ORF particles, 1500010J02Rik (Myc-DDK-tagged) - Mouse RIKEN cDNA 1500010J02 gene (cDNA clone MGC:79217 IMAGE:6847619), 200ul, >10^7 TU/mL
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CNY 11,875.00
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Specifications
| Product Data | |
| Product Name | 1500010J02Rik (BC060629) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | RP23-19I2.2 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | BC060629 |
| ORF Size | 2898 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR211335).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | BC060629.1 |
| RefSeq Size | 3247 bp |
| RefSeq ORF | 2900 bp |
| Locus ID | 68964 |
| Gene Summary | Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha. The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins. Involved in telomere maintenance. Involved in genome stability (By similarity). May be in involved in telomeric C-strand fill-in during late S/G2 phase (PubMed:22748632).[UniProtKB/Swiss-Prot Function] |
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