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Unc5b (BC057560) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR211242L3V
- LentiORF®
-
Lenti ORF particles, Unc5b (Myc-DDK-tagged) - Mouse unc-5 homolog B (C. elegans) (cDNA clone MGC:66787 IMAGE:6417563), 200ul, >10^7 TU/mL
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CNY 11,875.00
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Specifications
| Product Data | |
| Product Name | Unc5b (BC057560) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 6330415E02Rik; A630020F16; D10Bwg0792e; Unc5h2 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | BC057560 |
| ORF Size | 2802 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR211242).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | BC057560.1 |
| RefSeq Size | 3672 bp |
| RefSeq ORF | 2804 bp |
| Locus ID | 107449 |
| Gene Summary | Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis (PubMed:15510105). Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (PubMed:15510105). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity).[UniProtKB/Swiss-Prot Function] |
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