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Gba2 (NM_172692) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR211175L3V
- LentiORF®
-
Lenti ORF particles, Gba2 (Myc-DDK-tagged) - Mouse glucosidase beta 2 (Gba2), 200ul, >10^7 TU/mL
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CNY 14,250.00
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Specifications
| Product Data | |
| Product Name | Gba2 (NM_172692) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | F630034E04 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_172692 |
| ORF Size | 2754 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR211175).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_172692.3, NP_766280.2 |
| RefSeq Size | 3552 bp |
| RefSeq ORF | 2757 bp |
| Locus ID | 230101 |
| Gene Summary | Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide (PubMed:17080196, PubMed:23250757). Glucosylceramides are membrane glycosphingolipids that have a wide intracellular distribution (PubMed:23250757). They are the main precursors of more complex glycosphingolipids that play a role in cellular growth, differentiation, adhesion, signaling, cytoskeletal dynamics and membrane properties (PubMed:25803043). Also involved in the transglucosylation of cholesterol, transferring glucose from glucosylceramides, thereby modifying its water solubility and biological properties (PubMed:26724485). Under specific conditions, may catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide (PubMed:26724485). Finally, may also play a role in the metabolism of bile acids (PubMed:17080196). It is able to hydrolyze bile acid 3-O-glucosides but also to produce bile acid-glucose conjugates thanks to a bile acid glucosyl transferase activity (PubMed:17080196). However, the relevance of both activities is unclear in vivo (PubMed:17080196).[UniProtKB/Swiss-Prot Function] |
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