Wwp2 (NM_025830) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR211018L4V
- LentiORF®
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Lenti ORF particles, Wwp2 (GFP-tagged) - Mouse WW domain containing E3 ubiquitin protein ligase 2 (Wwp2), 200ul, >10^7 TU/mL
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CNY 15,295.00
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Specifications
Product Data | |
Product Name | Wwp2 (NM_025830) Mouse Tagged ORF Clone Lentiviral Particle |
Synonyms | 1300010O06Rik; AA690238; AIP2; AW554328 |
Vector | pLenti-C-mGFP-P2A-Puro |
ACCN | NM_025830 |
ORF Size | 2613 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR211018).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_025830.3 |
RefSeq Size | 4319 bp |
RefSeq ORF | 2613 bp |
Locus ID | 66894 |
Gene Summary | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; regulates POU5F1 protein level during differentiation of embryonal carcinoma cells (ECCs) but not in undifferentiated ECCs and embryonic stem cells (ESCs). Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.[UniProtKB/Swiss-Prot Function] |
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