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Fgfr4 (NM_008011) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR210769L2V
- LentiORF®
-
Lenti ORF particles, Fgfr4 (GFP-tagged) - Mouse fibroblast growth factor receptor 4 (Fgfr4), 200ul, >10^7 TU/mL
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CNY 14,345.00
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Specifications
| Product Data | |
| Product Name | Fgfr4 (NM_008011) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | Fgfr-4 |
| Vector | pLenti-C-mGFP |
| ACCN | NM_008011 |
| ORF Size | 2397 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR210769).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_008011.2, NP_032037.2 |
| RefSeq Size | 3146 bp |
| RefSeq ORF | 2400 bp |
| Locus ID | 14186 |
| Gene Summary | Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Plays a role in postnatal lung development. May be involved in the development of skeletal muscle cell lineages.[UniProtKB/Swiss-Prot Function] |
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