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Mapk7 (NM_011841) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR210486L4V
- LentiORF®
-
Lenti ORF particles, Mapk7 (GFP-tagged) - Mouse mitogen-activated protein kinase 7 (Mapk7), 200ul, >10^7 TU/mL
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CNY 14,440.00
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Specifications
| Product Data | |
| Product Name | Mapk7 (NM_011841) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | BMK-1; BMK1; ERK-5; ERK5; Erk5-T; PRKM7 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_011841 |
| ORF Size | 2418 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR210486).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_011841.1, NP_035971.1 |
| RefSeq Size | 2945 bp |
| RefSeq ORF | 2421 bp |
| Locus ID | 23939 |
| Gene Summary | Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression (By similarity). Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction (By similarity).[UniProtKB/Swiss-Prot Function] |
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