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Palb2 (BC066140) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR210399L4V
- LentiORF®
-
Lenti ORF particles, Palb2 (GFP-tagged) - Mouse partner and localizer of BRCA2 (cDNA clone MGC:76443 IMAGE:30459312), 200ul, >10^7 TU/mL
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CNY 13,205.00
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Specifications
| Product Data | |
| Product Name | Palb2 (BC066140) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 4732427B05 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | BC066140 |
| ORF Size | 2223 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR210399).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | BC066140, AAH66140 |
| RefSeq Size | 2568 bp |
| RefSeq ORF | 2225 bp |
| Locus ID | 233826 |
| Gene Summary | Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination. Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair. Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinational repair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation. Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity (By similarity).[UniProtKB/Swiss-Prot Function] |
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