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Rfwd2 (Cop1) (NM_011931) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR210351L3V
- LentiORF®
-
Lenti ORF particles, Rfwd2 (Myc-DDK-tagged) - Mouse ring finger and WD repeat domain 2 (Rfwd2), 200ul, >10^7 TU/mL
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CNY 12,160.00
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Specifications
| Product Data | |
| Product Name | Rfwd2 (Cop1) (NM_011931) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AI316802; C80879; Cop1; Rfwd2 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_011931 |
| ORF Size | 2199 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR210351).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_011931.3 |
| RefSeq Size | 5056 bp |
| RefSeq ORF | 2202 bp |
| Locus ID | 26374 |
| Gene Summary | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif.[UniProtKB/Swiss-Prot Function] |
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