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Uvrag (NM_178635) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR210112L4V
- LentiORF®
-
Lenti ORF particles, Uvrag (GFP-tagged) - Mouse UV radiation resistance associated gene (Uvrag), 200ul, >10^7 TU/mL
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CNY 13,110.00
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Specifications
| Product Data | |
| Product Name | Uvrag (NM_178635) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 9530039D02Rik; AI648770; BB124205; Uvrag1; Uvragl |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_178635 |
| ORF Size | 2094 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR210112).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_178635.2, NP_848750.2 |
| RefSeq Size | 3432 bp |
| RefSeq ORF | 2097 bp |
| Locus ID | 78610 |
| Gene Summary | Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P). During autophagy acts as regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3. Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2. Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events. Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion. In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly.[UniProtKB/Swiss-Prot Function] |
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