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Mapk8ip1 (BC072578) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR210109L3V
- LentiORF®
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Lenti ORF particles, Mapk8ip1 (Myc-DDK-tagged) - Mouse mitogen activated protein kinase 8 interacting protein 1 (cDNA clone MGC:99893 IMAGE:6402485), 200ul, >10^7 TU/mL
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CNY 11,875.00
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Specifications
| Product Data | |
| Product Name | Mapk8ip1 (BC072578) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | JIP-1, IB1 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | BC072578 |
| ORF Size | 2094 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR210109).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | BC072578, AAH72578 |
| RefSeq Size | 3138 bp |
| RefSeq ORF | 2096 bp |
| Locus ID | 19099 |
| Gene Summary | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response (By similarity). Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8(+) T-cells (PubMed:23963642).[UniProtKB/Swiss-Prot Function] |
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