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Gramd1a (BC018554) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR209732L3V
- LentiORF®
-
Lenti ORF particles, Gramd1a (Myc-DDK-tagged) - Mouse GRAM domain containing 1A (cDNA clone MGC:19375 IMAGE:2646082), 200ul, >10^7 TU/mL
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CNY 9,975.00
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Specifications
| Product Data | |
| Product Name | Gramd1a (BC018554) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 1300003M23Rik; AI415002; AW547240; D7Bwg0611e |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | BC018554 |
| ORF Size | 1941 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR209732).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | BC018554, AAH18554 |
| RefSeq Size | 2513 bp |
| RefSeq ORF | 1943 bp |
| Locus ID | 52857 |
| Gene Summary | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (PubMed:30220461). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (PubMed:30220461). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (PubMed:30220461). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (PubMed:30220461). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (PubMed:30220461). May play a role in tumor progression (PubMed:27585821).[UniProtKB/Swiss-Prot Function] |
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