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Wee1 (NM_009516) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR209724L3V
- LentiORF®
-
Lenti ORF particles, Wee1 (Myc-DDK-tagged) - Mouse WEE 1 homolog 1 (S. pombe) (Wee1), 200ul, >10^7 TU/mL
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CNY 11,210.00
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Specifications
| Product Data | |
| Product Name | Wee1 (NM_009516) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | Wee1A |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_009516 |
| ORF Size | 1941 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR209724).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_009516.3, NP_033542.2 |
| RefSeq Size | 3419 bp |
| RefSeq ORF | 1941 bp |
| Locus ID | 22390 |
| Gene Summary | Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation (By similarity).[UniProtKB/Swiss-Prot Function] |
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