Ajuba (NM_010590) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR208706L3V
- LentiORF®
-
Lenti ORF particles, Ajuba (Myc-DDK-tagged) - Mouse ajuba (Jub), 200ul, >10^7 TU/mL
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CNY 10,070.00
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Specifications
Product Data | |
Product Name | Ajuba (NM_010590) Mouse Tagged ORF Clone Lentiviral Particle |
Synonyms | Jub |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_010590 |
ORF Size | 1644 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR208706).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_010590.2 |
RefSeq Size | 3503 bp |
RefSeq ORF | 1644 bp |
Locus ID | 16475 |
Gene Summary | Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1.[UniProtKB/Swiss-Prot Function] |
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