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Parp3 (NM_145619) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR208459L4V
- LentiORF®
-
Lenti ORF particles, Parp3 (GFP-tagged) - Mouse poly (ADP-ribose) polymerase family, member 3 (Parp3), 200ul, >10^7 TU/mL
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CNY 10,925.00
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Specifications
| Product Data | |
| Product Name | Parp3 (NM_145619) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | A930002C11Rik; Adprt3; Adprtl3; AW990611; pADPRT-3; PARP-3 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_145619 |
| ORF Size | 1587 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR208459).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_145619.2 |
| RefSeq Size | 2633 bp |
| RefSeq ORF | 1587 bp |
| Locus ID | 235587 |
| Gene Summary | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage (PubMed:21270334, PubMed:24598253). Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins (By similarity). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (By similarity). Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks (PubMed:21270334). Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (By similarity). Cooperates with the XRRC6-XRCC5 (Ku70-Ku80) heterodimer to limit end-resection thereby promoting accurate NHEJ (PubMed:24598253). Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as XRRC5 and XRCC6 (By similarity). ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity). May link the DNA damage surveillance network to the mitotic fidelity checkpoint (By similarity). In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'- or 3'-terminal phosphate residues in DNA containing multiple strand breaks (By similarity). Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA /AID on the chromatin (PubMed:26000965).[UniProtKB/Swiss-Prot Function] |
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