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Parp3 (NM_145619) Mouse Untagged Clone
CAT＃: MC205926
Parp3 (untagged) - Mouse poly (ADP-ribose) polymerase family, member 3 (Parp3), (10ug)
CNY 2,000.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | A930002C11Rik; Adprt3; Adprtl3; AW990611; pADPRT-3; PARP-3 |
| Vector | PCMV6-Kan/Neo |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>BC058754
CGGGGAACACCTCGAGCCAACTGCTTCCTAACTCCAGGGTGGGCAGAACTGACGGGATCTAAGCTTCTGC ATCTCTGAGGAGAACCATGGCTCCAAAACGAAAGGCCTCTGTGCAGACTGAGGGCTCCAAGAAGCAGCGA CAAGGGACAGAGGAGGAGGACAGCTTCCGGTCCACTGCCGAGGCTCTCAGAGCAGCACCTGCTGATAATC GGGTCATCCGTGTGGACCCCTCATGTCCATTCAGCCGGAACCCCGGGATACAGGTCCACGAGGACTATGA CTGTACCCTGAACCAGACCAACATCGGCAACAACAACAACAAGTTCTATATTATCCAACTGCTGGAGGAG GGTAGTCGCTTCTTCTGCTGGAATCGCTGGGGCCGCGTGGGAGAGGTGGGCCAGAGCAAGATGAACCACT TCACCTGCCTGGAAGATGCAAAGAAGGACTTTAAGAAGAAATTTTGGGAGAAGACTAAAAACAAATGGGA GGAGCGGGACCGTTTTGTGGCCCAGCCCAACAAGTACACACTTATAGAAGTCCAGGGAGAAGCAGAGAGC CAAGAGGCTGTAGTGAAGGTGGACAGCGGCCCTGTGAGGACCGTGGTCAAGCCCTGCTCCCTAGACCCTG CCACCCAGAACCTTATCACCAACATCTTCAGCAAAGAGATGTTCAAGAACGCAATGACCCTCATGAACCT GGATGTGAAGAAGATGCCCTTGGGAAAGCTGACCAAGCAGCAGATTGCCCGTGGCTTCGAGGCCTTGGAA GCTCTAGAGGAGGCCATGAAAAACCCCACAGGGGATGGCCAGAGCCTGGAAGAGCTCTCCTCCTGCTTCT ACACTGTCATCCCACACAACTTCGGCCGCAGCCGACCCCCGCCCATCAACTCCCCTGATGTGCTTCAGGC CAAGAAGGACATGCTGCTGGTGCTAGCGGACATCGAGTTGGTGCAGACCTTGCAGGCAGCCCCTGGGGAG GAGGAGGAGAAAGTGGAAGAGGTGCCACACCCACTGGATCGAGACTACCAGCTCCTCAGGTGCCAGCTTC AACTGCTGGACTCCGGGGAGTCCGAGTACAAGGCAATACAGACCTACCTGAAACAGACTGGCAACAGCTA CAGGTGCCCAAACCTGCGGCATGTTTGGAAAGTGAACCGAGAAGGGGAGGGAGACAGGTTCCAGGCCCAC TCCAAACTGGGCAATCGGAGGCTGCTGTGGCACGGCACCAATGTGGCCGTGGTGGCTGCCATCCTCACCA GTGGGCTCCGAATCATGCCACACTCGGGTGGTCGTGTTGGCAAGGGTATTTATTTTGCCTCTGAGAACAG CAAGTCAGCTGGCTATGTTACCACCATGCACTGTGGGGGCCACCAGGTGGGCTACATGTTCCTGGGCGAG GTGGCCCTCGGCAAAGAGCACCACATCACCATCGATGACCCCAGCTTGAAGAGTCCACCCCCTGGCTTTG ACAGCGTCATCGCCCGAGGCCAAACCGAGCCGGATCCCGCCCAGGACATTGAACTTGAACTGGATGGGCA GCCGGTGGTGGTGCCCCAAGGCCCGCCTGTGCAGTGCCCGTCATTCAAAAGCTCCAGCTTCAGCCAGAGT GAATACCTCATATACAAGGAGAGCCAGTGTCGCCTGCGCTACCTGCTGGAGATTCACCTCTAAGCTGCTT GCCCTCCCCAGGTCCTGCCCTGCCGAGCCATGATCTTCACCCTCCTCTCCCTGGCTCTCACAGCACTTTG TCTGCCTCCCAGGAATATAATACATGCCAGGCATTGGCACACACCAGTAGCCTCAGCTACTCAGGGGGCA GAGGCAAGAAAAACACTTTATCCTGGGATCTGGACTCTCACCTAGGCTACATAGTAACACGTGTCTCAAA AAAAAAAAAAAAAAA |
| Restriction Sites | RsrII-NotI |
| ACCN | NM_145619 |
| Insert Size | 1587 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | BC058754, AAH58754 |
| RefSeq Size | 1905 bp |
| RefSeq ORF | 1587 bp |
| Locus ID | 235587 |
| UniProt ID | Q8CFB8 |
| Gene Summary | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage (PubMed:21270334, PubMed:24598253). Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins (By similarity). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (By similarity). Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks (PubMed:21270334). Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (By similarity). Cooperates with the XRRC6-XRCC5 (Ku70-Ku80) heterodimer to limit end-resection thereby promoting accurate NHEJ (PubMed:24598253). Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as XRRC5 and XRCC6 (By similarity). ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity). May link the DNA damage surveillance network to the mitotic fidelity checkpoint (By similarity). In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'- or 3'-terminal phosphate residues in DNA containing multiple strand breaks (By similarity). Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA /AID on the chromatin (PubMed:26000965).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG208459 | Parp3 (tGFP-tagged) - Mouse poly (ADP-ribose) polymerase family, member 3 (Parp3) |
CNY 5,040.00 |
|
| MR208459 | Parp3 (Myc-DDK-tagged) - Mouse poly (ADP-ribose) polymerase family, member 3 (Parp3) |
CNY 3,936.00 |
|
| MR208459L3 | Lenti ORF clone of Parp3 (Myc-DDK-tagged) - Mouse poly (ADP-ribose) polymerase family, member 3 (Parp3) |
CNY 6,460.00 |
|
| MR208459L4 | Lenti ORF clone of Parp3 (mGFP-tagged) - Mouse poly (ADP-ribose) polymerase family, member 3 (Parp3) |
CNY 6,460.00 |
