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Clk2 (NM_001163432) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR207997L3V
- LentiORF®
-
Lenti ORF particles, Clk2 (Myc-DDK-tagged) - Mouse CDC-like kinase 2 (Clk2), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 9,975.00
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Specifications
| Product Data | |
| Product Name | Clk2 (NM_001163432) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AU041688 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001163432 |
| ORF Size | 1497 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR207997).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001163432.1, NP_001156904.1 |
| RefSeq Size | 2307 bp |
| RefSeq ORF | 1497 bp |
| Locus ID | 12748 |
| Gene Summary | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.[UniProtKB/Swiss-Prot Function] |
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