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Tmprss2 (NM_015775) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR207852L3V
- LentiORF®
-
Lenti ORF particles, Tmprss2 (Myc-DDK-tagged) - Mouse transmembrane protease, serine 2 (Tmprss2), 200ul, >10^7 TU/mL
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CNY 9,405.00
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Specifications
| Product Data | |
| Product Name | Tmprss2 (NM_015775) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | D16Ertd61e |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_015775 |
| ORF Size | 1473 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR207852).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_015775.2, NP_056590.2 |
| RefSeq Size | 3175 bp |
| RefSeq ORF | 1473 bp |
| Locus ID | 50528 |
| Gene Summary | Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions. The spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9) and is involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.[UniProtKB/Swiss-Prot Function] |
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