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Mdm2 (NM_010786) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR207827L4V
- LentiORF®
-
Lenti ORF particles, Mdm2 (GFP-tagged) - Mouse transformed mouse 3T3 cell double minute 2 (Mdm2), 200ul, >10^7 TU/mL
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CNY 10,545.00
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Specifications
| Product Data | |
| Product Name | Mdm2 (NM_010786) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 1700007J15Rik; AA415488; Mdm-2 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_010786 |
| ORF Size | 1470 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR207827).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_010786.2 |
| RefSeq Size | 3124 bp |
| RefSeq ORF | 1470 bp |
| Locus ID | 17246 |
| Gene Summary | E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome (PubMed:15195100, PubMed:21804542). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain (By similarity). Also acts as a ubiquitin ligase E3 toward itself, ARRB1 and ARBB2 (PubMed:11588219). Permits the nuclear export of p53/TP53 (By similarity). Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein (By similarity). Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation (By similarity). Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53 (By similarity). Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways (By similarity). Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus (By similarity). Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (By similarity). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (PubMed:25088421). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (PubMed:14642282).[UniProtKB/Swiss-Prot Function] |
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