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Klhl18 (BC025563) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR206865L3V
- LentiORF®
-
Lenti ORF particles, Klhl18 (Myc-DDK-tagged) - Mouse kelch-like 18 (Drosophila) (cDNA clone MGC:36415 IMAGE:5322893), 200ul, >10^7 TU/mL
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CNY 9,975.00
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Specifications
| Product Data | |
| Product Name | Klhl18 (BC025563) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | A930041K15, MGC36415 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | BC025563 |
| ORF Size | 1290 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR206865).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | BC025563, AAH25563 |
| RefSeq Size | 4559 bp |
| RefSeq ORF | 1292 bp |
| Locus ID | 270201 |
| Gene Summary | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis (By similarity). The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading to its activation at the centrosome which is required for initiating mitotic entry (By similarity). Regulates light- and dark-dependent alpha-transducin localization changes in rod photoreceptors through UNC119 ubiquitination and degradation (PubMed:31696965). Preferentially ubiquitinates the unphosphorylated form of UNC119 over the phosphorylated form (PubMed:31696965). In the presence of UNC119, under dark-adapted conditions alpha-transducin mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light (PubMed:31696965).[UniProtKB/Swiss-Prot Function] |
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