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Terf2ip (BC017641) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR206145L2V
- LentiORF®
-
Lenti ORF particles, Terf2ip (GFP-tagged) - Mouse telomeric repeat binding factor 2, interacting protein (cDNA clone MGC:28971 IMAGE:4483320), 200ul, >10^7 TU/mL
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CNY 11,115.00
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Specifications
| Product Data | |
| Product Name | Terf2ip (BC017641) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | Rap1 |
| Vector | pLenti-C-mGFP |
| ACCN | BC017641 |
| ORF Size | 1179 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR206145).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | BC017641, AAH17641 |
| RefSeq Size | 2122 bp |
| RefSeq ORF | 1181 bp |
| Locus ID | 57321 |
| Gene Summary | Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.[UniProtKB/Swiss-Prot Function] |
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