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Dmtn (NM_013514) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR205979L3V
- LentiORF®
-
Lenti ORF particles, Epb4.9 (Myc-DDK-tagged) - Mouse erythrocyte protein band 4.9 (Epb4.9), 200ul, >10^7 TU/mL
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CNY 7,410.00
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Specifications
| Product Data | |
| Product Name | Dmtn (NM_013514) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AI325486; dematin; Epb4.9; Epb49 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_013514 |
| ORF Size | 1152 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR205979).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_013514.3, NP_038542.1 |
| RefSeq Size | 4129 bp |
| RefSeq ORF | 1152 bp |
| Locus ID | 13829 |
| Gene Summary | Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.[UniProtKB/Swiss-Prot Function] |
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