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Vps26b (NM_178027) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR204988L4V
- LentiORF®
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Lenti ORF particles, Vps26b (GFP-tagged) - Mouse vacuolar protein sorting 26 homolog B (yeast) (Vps26b), 200ul, >10^7 TU/mL
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CNY 8,360.00
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Specifications
| Product Data | |
| Product Name | Vps26b (NM_178027) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 1810012I05Rik; 2310075A12Rik; AI848392 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_178027 |
| ORF Size | 1011 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR204988).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_178027.3 |
| RefSeq Size | 6890 bp |
| RefSeq ORF | 1011 bp |
| Locus ID | 69091 |
| Gene Summary | Acts as component of the retromer cargo-selective complex (CSC) (PubMed:21040701, PubMed:21920005). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (By similarity). May be involved in retrograde transport of SORT1 but not of IGF2R (PubMed:21040701). Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (PubMed:25136126).[UniProtKB/Swiss-Prot Function] |
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