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Ndel1 (BC021434) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR204509L3V
- LentiORF®
-
Lenti ORF particles, Ndel1 (Myc-DDK-tagged) - Mouse nuclear distribution gene E-like homolog 1 (A, 200ul, >10^7 TU/mL
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CNY 9,975.00
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Specifications
| Product Data | |
| Product Name | Ndel1 (BC021434) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | NUDEL, MITAP1 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | BC021434 |
| ORF Size | 945 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR204509).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | BC021434, AAH21434 |
| RefSeq Size | 1654 bp |
| RefSeq ORF | 947 bp |
| Locus ID | 83431 |
| Gene Summary | Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (PubMed:27777970).[UniProtKB/Swiss-Prot Function] |
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