Fbxo6 (NM_001163704) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR204081L4V
- LentiORF®
Lenti ORF particles, Fbxo6 (GFP-tagged) - Mouse F-box protein 6 (Fbxo6), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 11,115.00
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Specifications
Product Data | |
Product Name | Fbxo6 (NM_001163704) Mouse Tagged ORF Clone Lentiviral Particle |
Synonyms | AA408845; FBG2; Fbs2; Fbx6b; Fbxo6b |
Vector | pLenti-C-mGFP-P2A-Puro |
ACCN | NM_001163704 |
ORF Size | 888 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR204081).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_001163704.1, NP_001157176.1 |
RefSeq Size | 1429 bp |
RefSeq ORF | 888 bp |
Locus ID | 50762 |
Gene Summary | Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication (By similarity). Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans.[UniProtKB/Swiss-Prot Function] |
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