United States
Germany
Japan
United Kingdom
China
Lair1 (NM_001113474) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR203475L4V
- LentiORF®
-
Lenti ORF particles, Lair1 (GFP-tagged) - Mouse leukocyte-associated Ig-like receptor 1 (Lair1), transcript variant a, 200ul, >10^7 TU/mL
Need custom lentivirus service?
Get a free quote
CNY 8,360.00
货期*
详询
规格
Product images
经常一起买 (2)
Specifications
| Product Data | |
| Product Name | Lair1 (NM_001113474) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 5133400O11Rik; BB115266; D7Bwg0421e; Lair-1 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_001113474 |
| ORF Size | 792 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR203475).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001113474.1, NP_001106945.1 |
| RefSeq Size | 3512 bp |
| RefSeq ORF | 792 bp |
| Locus ID | 52855 |
| Gene Summary | Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells (By similarity).[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
You may also need
Customer
Reviews
Loading...
