LPHN2 (ADGRL2) (NM_001297705) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	CIRL2; CL2; LEC1; LPHH1; LPHN2
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >NCBI ORF sequence for NM_001297705, the custom clone sequence may differ by one or more nucleotides ATGGTGTCTTCTGGTTGCAGAATGCGAAGTCTGTGGTTTATCATTGTAATCAGCTTCTTACCAAATACAG AAGGTTTCAGCAGAGCAGCTTTACCATTTGGGCTGGTGAGGCGAGAATTATCCTGTGAAGGTTATTCTAT AGATCTGCGATGCCCGGGCAGTGATGTCATCATGATTGAGAGCGCTAACTATGGTCGGACGGATGACAAG ATTTGTGATGCTGACCCATTTCAGATGGAGAATACAGACTGCTACCTCCCCGATGCCTTCAAAATTATGA CTCAAAGGTGCAACAATCGAACACAGTGTATAGTAGTTACTGGGTCAGATGTGTTTCCTGATCCATGTCC TGGAACATACAAATACCTTGAAGTCCAATATGAATGTGTCCCTTACATTTTTGTGTGTCCTGGGACCTTG AAAGCAATTGTGGACTCACCATGTATATATGAAGCTGAACAAAAGGCGGGTGCTTGGTGCAAGGACCCTC TTCAGGCTGCAGATAAAATTTATTTCATGCCCTGGACTCCCTATCGTACCGATACTTTAATAGAATATGC TTCTTTAGAAGATTTCCAAAATAGTCGCCAAACAACAACATATAAACTTCCAAATCGAGTAGATGGTACT GGATTTGTGGTGTATGATGGTGCTGTCTTCTTTAACAAAGAAAGAACGAGGAATATTGTGAAATTTGACT TGAGGACTAGAATTAAGAGTGGCGAGGCCATAATTAACTATGCCAACTACCATGATACCTCACCATACAG ATGGGGAGGAAAGACTGATATCGACCTAGCAGTTGATGAAAATGGTTTATGGGTCATTTACGCCACTGAA CAGAACAATGGAATGATAGTTATTAGCCAGCTGAATCCATACACTCTTCGATTTGAAGCAACGTGGGAGA CTGTATACGACAAACGTGCCGCATCAAATGCTTTTATGATATGCGGAGTCCTCTATGTGGTTAGGTCAGT TTATCAAGACAATGAAAGTGAAACAGGCAAGAACTCAATTGATTACATTTATAATACCCGATTAAACCGA GGAGAATATGTAGATGTTCCCTTCCCCAACCAGTATCAGTATATTGCTGCAGTGGATTACAATCCAAGAG ATAACCAACTTTACGTGTGGAACAATAACTTCATTTTACGATATTCTCTGGAGTTTGGTCCACCTGATCC TGCCCAAGTGCCTACCACAGCTGTGACAATAACTTCTTCAGCTGAGCTGTTCAAAACCATAATATCAACC ACAAGCACTACTTCACAGAAAGGCCCCATGAGCACAACTGTAGCTGGATCACAGGAAGGAAGCAAAGGGA CAAAACCACCTCCAGCAGTTTCTACAACCAAAATTCCACCTATAACAAATATTTTTCCCCTGCCAGAGAG ATTCTGTGAAGCATTAGACTCCAAGGGGATAAAGTGGCCTCAGACACAAAGGGGAATGATGGTTGAACGA CCATGCCCTAAGGGAACAAGAGGAACTGCCTCATATCTCTGCATGATTTCCACTGGAACATGGAACCCTA AGGGCCCCGATCTTAGCAACTGTACCTCACACTGGGTGAATCAGCTGGCTCAGAAGATCAGAAGCGGAGA AAATGCTGCTAGTCTTGCCAATGAACTGGCTAAACATACCAAAGGGCCAGTGTTTGCTGGGGATGTAAGT TCTTCAGTGAGATTGATGGAGCAGTTGGTGGACATCCTTGATGCACAGCTGCAGGAACTGAAACCTAGTG AAAAAGATTCAGCTGGACGGAGTTATAACAAGGCAATTGTTGACACAGTGGACAACCTTCTGAGACCCGA AGCTTTGGAATCATGGAAACATATGAATTCTTCTGAACAAGCACATACTGCAACAATGTTACTCGATACA TTGGAAGAAGGAGCTTTTGTCCTAGCTGACAATCTTTTAGAACCAACAAGGGTCTCAATGCCCACAGAAA ATATTGTCCTGGAAGTTGCCGTACTCAGTACAGAAGGACAGATCCAAGACTTTAAATTTCCTCTGGGCAT CAAAGGAGCAGGCAGCTCAATCCAACTGTCCGCAAATACCGTCAAACAGAACAGCAGGAATGGGCTTGCA AAGTTGGTGTTCATCATTTACCGGAGCCTGGGACAGTTCCTTAGTACAGAAAATGCAACCATTAAACTGG GTGCTGATTTTATTGGTCGTAATAGCACCATTGCAGTGAACTCTCACGTCATTTCAGTTTCAATCAATAA AGAGTCCAGCCGAGTATACCTGACTGATCCTGTGCTTTTTACCCTGCCACACATTGATCCTGACAATTAT TTCAATGCAAACTGCTCCTTCTGGAACTACTCAGAGAGAACTATGATGGGATATTGGTCTACCCAGGGCT GCAAGCTGGTTGACACTAATAAAACTCGAACAACGTGTGCATGCAGCCACCTAACCAATTTTGCAATTCT CATGGCCCACAGGGAAATTGCATATAAAGATGGCGTTCATGAATTACTTCTTACAGTCATCACCTGGGTG GGAATTGTCATTTCCCTTGTTTGCCTGGCTATCTGCATCTTCACCTTCTGCTTTTTCCGTGGCCTACAGA GTGACCGAAATACTATTCACAAGAACCTTTGTATCAACCTTTTCATTGCTGAATTTATTTTCCTAATAGG CATTGATAAGACAAAATATGCGATTGCATGCCCAATATTTGCAGGACTTCTACACTTTTTCTTTTTGGCA GCTTTTGCTTGGATGTGCCTAGAAGGTGTGCAGCTCTACCTAATGTTAGTTGAAGTTTTTGAAAGTGAAT ATTCAAGGAAAAAATATTACTATGTTGCTGGTTACTTGTTTCCTGCCACAGTGGTTGGAGTTTCAGCTGC TATTGACTATAAGAGCTATGGAACAGAAAAAGCTTGCTGGCTTCATGTTGATAACTACTTTATATGGAGC TTCATTGGACCTGTTACCTTCATTATTCTGCTAAATATTATCTTCTTGGTGATCACATTGTGCAAAATGG TGAAGCATTCAAACACTTTGAAACCAGATTCTAGCAGGTTGGAAAACATTAAGTCTTGGGTGCTTGGCGC TTTCGCTCTTCTGTGTCTTCTTGGCCTCACCTGGTCCTTTGGGTTGCTTTTTATTAATGAGGAGACTATT GTGATGGCATATCTCTTCACTATATTTAATGCTTTCCAGGGAGTGTTCATTTTCATCTTTCACTGTGCTC TCCAAAAGAAAGTACGAAAAGAATATGGCAAGTGCTTCAGACACTCATACTGCTGTGGAGGCCTCCCAAC TGAGAGTCCCCACAGTTCAGTGAAGGCATCAACCACCAGAACCAGTGCTCGCTATTCCTCTGGCACACAG AGTCGTATAAGAAGAATGTGGAATGATACTGTGAGAAAACAATCAGAATCTTCTTTTATCTCAGGTGACA TCAATAGCACTTCAACACTTAATCAAGGACTGACATCACATGGTCTGAGAGCCCATCTTCAAGATTTATA TCATTTAGAGCTACTCTTAGGCCAGATAGCCTGA
Restriction Sites	SgfI-MluI
ACCN	NM_001297705
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001297705.1, NP_001284634.1
RefSeq Size	6127 bp
RefSeq ORF	3534 bp
Locus ID	23266
UniProt ID	O95490
Protein Families	Druggable Genome, GPCR, Transmembrane
Gene Summary	This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] Transcript Variant: This variant (3) lacks an alternate in-frame exon and contains two alternate exons in the 3' coding region, which results in a frameshift, compared to variant 5. The encoded isoform (2) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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