SIN3B (NM_001297595) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >NCBI ORF sequence for NM_001297595, the custom clone sequence may differ by one or more nucleotides ATGGCGCACGCTGGCGGTGGCAGCGGTGGCAGCGGTGCCGGCGGCCCCGCGGGCCGGGGGCTGAGCGGCG CCCGCTGGGGTCGCTCGGGCTCCGCAGGCCACGAGAAGCTGCCGGTGCACGTAGAAGACGCCCTCACCTA TCTGGACCAGGTGAAGATCCGCTTTGGCAGCGACCCTGCCACCTACAACGGCTTCCTGGAGATCATGAAG GAGTTCAAAAGCCAGAGCATCGATACTCCTGGAGTCATCAGACGTGTCTCGCAGCTCTTCCACGAGCACC CTGACCTCATTGTTGGATTCAACGCTTTTCTTCCCCTCGGATATAGAATAGACATTCCCAAGAATGGCAA GTTAAACATACAGTCGCCTCTGACAAGCCAGGAGAATTCGCACAACCACGGGGACGGTGCAGAGGACTTC AAGCAGCAGGTGCCGTATAAAGAGGACAAACCCCAGGTGCCCCTGGAGTCCGATTCCGTGGAATTCAACA ACGCCATCAGCTATGTGAATAAGATTAAAACCCGCTTCCTAGACCACCCAGAAATCTACAGGTCATTCCT GGAGATCCTGCACACGTACCAGAAGGAGCAGCTGAACACGAGGGGCCGGCCATTCCGAGGCATGTCTGAA GAGGAGGTGTTCACCGAGGTGGCCAACCTCTTCCGGGGCCAGGAGGACCTGCTCTCAGAGTTTGGACAGT TCCTGCCCGAAGCCAAGCGGTCTCTGTTCACAGGAAACGGGCCGTGCGAGATGCACAGCGTGCAGAAGAA CGAGCACGACAAGACCCCGGAGCACAGCAGGAAGCGCTCCCGGCCCTCGCTCCTCCGCCCCGTGTCTGCA CCCGCCAAGAAAAAAATGAAACTTCGTGGTACCAAAGACCTGTCCATCGCTGCAGTGGGGAAGTACGGGA CTCTGCAGGAATTTTCTTTCTTTGACAAGGTCCGCCGGGTGCTGAAGAGCCAGGAGGTGTATGAAAACTT CCTCCGCTGCATCGCACTCTTCAACCAGGAGCTGGTGTCTGGCTCTGAGCTCCTGCAGCTCGTCAGCCCA TTTCTGGGGAAATTTCCAGAACTCTTTGCACAGTTCAAGTCCTTCCTGGGGGTAAAAGAGCTGTCCTTCG CGCCACCCATGAGCGACAGATCCGGGGACGGGATAAGCCGGGAAATTGATTATGCATCCTGCAAGCGCAT AGGATCCAGCTACCGGGCACTCCCCAAAACCTACCAGCAGCCCAAGTGCAGTGGGAGGACAGCCATCTGC AAGGAGGTACTGAACGACACCTGGGTCTCCTTCCCTTCCTGGTCTGAGGACTCCACGTTCGTCAGCTCCA AGAAGACACCGTACGAGGAGCAGCTTCACCGCTGTGAGGACGAGCGCTTCGAGTTAGACGTTGTCCTGGA GACGAACCTGGCCACAATCCGTGTGTTGGAAAGTGTGCAGAAGAAGCTGTCTCGGATGGCGCCGGAAGAC CAGGAGAAGTTCCGGCTGGACGACTCCCTGGGAGGCACGTCGGAGGTGATCCAGCGCCGTGCCATTTATC GCATCTATGGCGACAAGGCCCCGGAGATCATCGAGAGCCTCAAGAAGAACCCTGTCACCGCTGTCCCCGT TGTCCTGAAAAGACTGAAGGCCAAGGAAGAGGAGTGGCGGGAGGCCCAGCAGGGCTTCAACAAGATCTGG CGGGAGCAGTATGAGAAGGCGTACCTCAAGTCCCTTGACCACCAGGCTGTGAACTTCAAGCAGAACGACA CCAAGGCCCTGCGCTCCAAGAGCTTGCTCAACGAGATCGAGAGCGTCTACGACGAGCACCAGGAGCAGCA CTCGGAGGGCCGCAGTGCCCCCTCTAGCGAGCCGCACCTCATCTTTGTGTACGAGGACCGGCAGATCCTG GAGGACGCAGCAGCGCTCATCAGCTACTACGTGAAGCGGCAGCCGGCCATCCAGAAGGAGGACCAGGGCA CCATCCACCAGCTGCTGCACCAGTTCGTGCCCAGCCTCTTCTTCTCTCAGCAGCTGGACCTGGGCGCCTC CGAGGAGTCAGCTGATGAGGACCGGGACAGCCCCCAGGGGCAGACCACAGACCCCAGTGAGCGGAAGAAG CCGGCGCCAGGACCCCACAGTAGCCCCCCAGAGGAGAAGGGGGCCTTCGGGGATGCCCCGGCCACTGAGC AGCCACCCCTGCCGCCCCCAGCCCCGCACAAGCCCCTGGACGATGTCTACAGCCTATTTTTTGCCAACAA CAACTGGTACTTCTTCCTGCGCCTGCACCAGACCCTGTGCTCCAGGCTGCTGAAGATCTACCGCCAGGCG CAGAAGCAGCTTCTGGAGTATCGGACCGAGAAGGAGCGGGAGAAGCTGCTGTGTGAGGGCCGCAGGGAGA AGGGCAGCGACCCCGCCATGGAGCTGCGGCTGAAGCAGCCCAGTGAAGTGGAGCTGGAGGAGTACTACCC GGCCTTCCTGGACATGGTGCGGAGCCTGCTGGAGGGCAGCATCGACCCCACGCAGTACGAGGACACCCTA CGCGAGATGTTCACCATCCATGCCTACGTGGGCTTCACCATGGACAAGCTGGTGCAGAACATTGCGCGGC AGCTGCACCACCTCGTGAGCGATGACGTCTGCCTGAAGGTGGTGGAGCTCTACCTGAACGAGAAGAAGCG GGGTGCCGCTGGTGGGAACCTGTCCTCCCGCTGCGTCCGCGCTGCTAGGGAGACCAGCTACCAGTGGAAG GCTGAGCGCTGCATGGCCGACGAGAACTGCTTCAAGGTGATGTTCCTGCAGCGCAAAGGGCAGGTGATCA TGACCATCGAGCTCCTGGACACCGAGGAGGCCCAGACGGAGGACCCTGTGGAGGTCCAGCACCTGGCTCG GTACGTGGAGCAGTATGTGGGGACCGAGGGCGCGTCCAGCTCGCCCACTGAGGGCTTCCTCCTGAAACCT GTGTTCCTGCAGAGGAACCTCAAGAAGTTCCGCCGCCGGTGGCAGAGCGAGCAGGCGCGGGCCCTGCGCG GTGAGGCCAGGAGCTCCTGGAAGCGGCTGGTGGGCGTGGAGAGCGCCTGCGACGTGGACTGCCGCTTCAA GCTCAGCACTCACAAGATGGTGTTCATCGTGAACTCCGAGGACTACATGTACCGTCGCGGGACCCTCTGC CGGGCCAAGCAGGTGCAGCCCCTGGTCCTGCTCCGCCACCACCAGCACTTTGAGGAGTGGCACAGCCGCT GGCTGGAGGACAATGTGACGGTGGAGGCGGCTAGCCTGGTGCAGGACTGGCTGATGGGTGAGGAGGACGA GGACATGGTACCCTGCAAGACGCTGTGTGAGACAGTGCACGTGCACGGCCTGCCCGTGACCCGCTACCGC GTGCAGTACAGCCGCCGCCCGGCCTCGCCCTGA
Restriction Sites	SgfI-MluI
ACCN	NM_001297595
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001297595.1, NP_001284524.1
RefSeq Size	5053 bp
RefSeq ORF	3393 bp
Locus ID	23309
UniProt ID	O75182
Gene Summary	Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.

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